Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics

Prognostic impact of high ABC transporter activity in 111 adult acute myeloid leukemia patients with normal cytogenetics when compared to FLT3, NPM1, CEBPA and BAALC.

ATP-binding cassette transporter (and specially P-glycoprotein) activity is a well known prognostic factor in acute myeloid leukemia, but when compared to other molecular markers its prognostic value has not been well studied. Here we study relationships between this activity, fms-like tyro-sine kinase 3(FLT3/ITD), nucleophosmin(NPM1), CAAT-enhancer binding protein alpha(CEBPα), and brain and a...

Analysis of BAALC gene Expression as prognosis factor in Pediatric Acute Myeloid Leukemia in Iran

Background:Brain and Acute Leukemia Cytoplasmic (BAALC) is a gene which its expression is confined to progenitor cells; therefore, no expression has been illustrated in mature cells of bone marrow or white blood cells (WBC).  In addition, high BAALC expression is associated with poor prognosis in Acute Myeloid Leukemia (AML) individuals and is considered as an important risk factor in Cyto...

Molecular Markers for Risk Stratification in Adult Acute Myeloid Leukemia with Normal Cytogenetics

Acute Myeloid Leukemia

The overall prognosis for adult acute myeloid leukemia (AML) remains poor. Cytogenetic analysis provides the major prognostic information, but more than 40% of patients have normal cytogenetics (CN-AML). In these cases, many molecular alterations with prognostic significance have been described to guide treatment. Mutations involving nucleophosmin (NPM1) and the CCAAT/enhancer binding protein a...

Molecular Biomarkers in Cytogenetically Normal –Acute Myeloid Leukemia: harnessing the targets

Cytogenetics based risk adapted therapy has set the stage for personalized medicine for Acute Myeloid Leukemia but 50% of Acute Myeloid Leukemia cases exhibit normal cytogenetics. With the molecular techniques mutations like NPM1, CEBPA and FLT3-ITD have been discovered and are recommended by WHO and ELN. These are molecular prognostic biomarkers which have refined the risk stratification resul...

Prognostic Value of BAALC Expression in Pediatric Acute Myeloid Leukemia: A Systematic Review

Background: Acute myeloid leukemia (AML) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. In cytogenetically normal AML (CN AML), molecular abnormalities in NPM, FLT3, CEBPA, and BAALC genes are observed. Initially, high BAALC (Brain and Acute Leukemia Cytoplasmic gene) expression was introduced in a study on AM...